in-vivo, in-vitro, cell biology, FACS, cancer, immunology, cardiovascular etc.

QUALIFICATION PROFILE Innovative Research Scientist in Cancer, Immunology, Cardiovascular and other therapeutic fields, highly skilled in in vivo and good experience in Cell Biology, independently work on many scientific projects. • Good experience in vitro background. Involved in insulin receptor signal transduction, B-RAF, PDK1 programs etc. Conducted PI3 kinase assay by immunoprecipitation, protein signaling assay by Western Blotting, pErk and pPDK1 assay by ELISA; Lipoprotein-Associated Phospholipase A2 activity assay for vascular atherosclerosis • In depth experience for animal model development and animal surgery as well as good experience with in vitro studies (include DMPK, FACS), excellent surgical skills, knowledge in oncology, physiology, pathology, biology and immunology, developed many successful animal models in different therapeutic areas especially for oncology, immunology, cardiovascular studies. • Involved in many projects while working in Eli Lilly and GSK, such as targets on Angiogenesis, AKT, IGF-1R, B-Raf, PI3K, TGF-b, MEK, Aurora, PDK1 and PERK etc. Developed many animal models for cancer and cardiovascular such as orthotopic and xenograft tumor models, intravenously continuous infusion in mouse and rat, renal capsule grafting model in mouse, orthotopic hepatoma model in mouse and rat, corneal micro-pocket model in rat and mouse, small bowel and heart transplantation in rat and mouse, DSI implanted into left ventricular in dog, vascular intracardiac catheterization in rat and mouse, etc. Set up animal models for compound screening and evaluation for different projects by PD/PK assay and efficacy studies.. • Experienced in scientific teaching and training to research technicians and graduate students. • Initiated and maintained numerous successful scientific collaborations. • Experienced with computer programs for data analysis using Excel, GraphPad Prism 5, etc.

Biologist

Norristown, PA