Description
PROFILE Highly skilled and innovative Research Scientist with an extensive industry background in molecular biology, clinical diagnostics, preclinical pharmacology, instrumentation and assay development, validation, applications, bioinformatics, and laboratory automation. Broad experience leading, managing, and mentoring multi-level scientists in dynamic cross functional environments. Motivated to identify, pursue, and lead all opportunities to increase efficiency, quality, intellectual property, and profitability. spec Clinical molecular diagnostics laboratory, production sequencing and genotyping, cardiology genetic and oncology pharmacogenomic tests. * Developed genetic & pharmacogenomic tests for a highly complex CLIA/CLEP laboratory on sequencing and genotyping platforms. * Managed biomarker development, assay/fragment/primer design, sequencing and genotyping optimizations, troubleshooting, data analysis/bioinformatics, and provided technical/scientific guidance/training to all production staff. * Designed assays for regions of interest containing 70+ genes, 900+ amplicons, validated and implemented into production CLIA laboratory molecular diagnostic tests. Invented a novel pharmacogenomic assay in a high complexity region for a cancer drug biomarker, patented. * Developed genotyping & copy number variation (CNV) tests and platforms, CNV analysis and reporting algorithms, worklist generators, & data analysis programs which dramatically increased the quality/efficiency of production and R&D processes and LIMS data entry. * Increased new test development fragment design pass rates from 57% to 89%, which led to 98% 1st pass coverage of all regions of interest. * Transition team member, consultant, inventor, key contributor, intellectual property patent transfer and support. genomic & genetic analysis instrumentation assays consumables. * Managed & ran feasibility studies pilot studies and research collaborations. Provided genotyping gene expression methylation analysis and molecular typing training and support. * Developed assay & study designs process optimizations troubleshooting and data analysis/bioinformatics. Low volume liquid handlers- high-throughput multi-format dispensing work-cell integration. * Managed and provided applications & technical support of automated liquid handling systems used for genomics proteomics and HTS in the US and Canada for customers and field sales.
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