Description
Qualifications / Achievements * Experienced in designation and preformation of molecular biology experiments, such as PCR, RT-PCR & real-time PCR Western blot, immunoprecipitation/Co-IP & ELISAs DNA cloning, DNA/RNA extraction & electrophoresis, etc. * Experienced in histopathology analysis, flow cytometry, immunofluorescence and immunochemistry, and related techniques of tissue dissecting of paraffin and crystal. * Developed cancer cell lines Induced human neurons from NT2 cell line Experience in tissue culture including primary tissues, cell lines, yeasts and bacteria, and related techniques of cell activation, proliferation and apoptosis. * Created transgenic animals, developed cancer metastasis mouse models Experience of mouse colonies maintenance, and related techniques of mouse surgeries, xenograft, genotypes, injections, necropsy, lavage, and nasal dosing etc. Inhibitors of cell signaling pathway in T-cell lymphomas and macrophages associated TCR engagement promotes resistance to chemotherapy in T-cell lymphomas in an ITK and GATA-3-dependent manner. Investigated GATA-3 regulates IL-10 production and macrophage polarization in T-cell lymphomas JAK2/FLT3 inhibitor depletes CLL-associated macrophages and impairs CLL cell viability. Generated T-cell lymphoma mouse models using transgenic mice and xenografts. Performed and supported projects at lab by real-time PCRs Western blots immunoprecipitation/Co-IP and ELISAs
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