Description
Project summary: Apomimetic peptides are novel drug candidates to treat atherosclerosis because of their ability to mimic the native apolipoprotein functions. Human PON1 (Paraoxonase1) activity was known to increase in presence of apomimetic peptide-lipid complexes. This increase in PON1 activity may be attributed to 'alterations' in secondary structural components (possibly tertiary structure) of PON1. The project includes analysis of secondary structural changes of PON1 in presence and absence of apomimetic peptide-lipid complexes by using ATR-FTIR spectroscopy.
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