Highlights:
1. First report of vascular effects of and non-selective endothelin receptor agonists and antagonists in humans (Lancet 1994 [>300 citations] and Circulation 1995 & 1996).
2. Seminal paper on the effects of leptin on sympathetic nerve activity (JCI 1997; >500 citations). Followed by over 20 papers on cardiovascular and metabolic regulation in obesity, including recent papers in Diabetes (2008) and JCI (2004).
3. Austin Doyle Young Investigator Award - International Society of Hypertension 1998.
4. Demonstration that inhibition of xanthine oxidase activity reverses vascular damage caused by smoking in humans (Circulation 2003, ATVB 2007).
5. Elected member, American Society of Clinical Investigation
6. Recent development of multidisciplinary research teams exploring links between subclinical vascular phenotypes and kidney disease (both renal transplant and ESRD), and also psychiatric disease (both cognitive decline and atypical antipsychotic use).
Companies I like:
Merck, Pfizer, Abbott, Roche, GSK, Astra-Zeneca, BMS, Genetech, innovative biotech companies.
Major advances in understanding of mechanisms of obesity and atherosclerosis