Description
PROFILE Result oriented team player with a strong expertise in medicinal/organic chemistry and successful track record in product development, project management, manufacturing support and new projects initiation. Career Highlights * Worked on syntheses of various receptors agonists for the diseases associated with metabolic disorders and ions imbalance * Identified RDX98940, gut-restricted TGR5 agonist, as development candidate for type 2 diabetes, short bowel syndrome and chemo-induced diarrhea * Identified RDX99848, minimally absorbed farnesoid X receptor agonist, as development candidate for treatment of liver diseases Non-alcoholic fatty liver disease (NAFLD), Non- alcoholic steatohepatitis (NASH) * Novel drug discovery resulting in the identification of Phase I human clinical candidate in infectious disease * Experience in the synthesis of small molecules as inhibitors of metalloenzymes * Synthesized sulfated and sialylated oligosaccharides as human immunodeficiency virus (HIV) and neuraminidase inhibitors * Extensive experience in peptide, glycopeptides, peptidomimetic and oligosaccharide synthesis and their purification * Synthesis of stable redox active endogenous compounds for the treatment of viral and bacterial conjunctivitis * Extensive experiences in structure activity relationship (SAR) rational, structure- based and mechanism-based drug design and large scale-up of compounds * Medicinal chemistry: Hit to Lead, and Lead Optimization pharmacokinetics property to improve bioavailability and reduce ADME/Tox liabilities while maintaining potency * Proven track record in delivering to aggressive project delivery targets punctually and beyond expectations of partner companies and collaborators * Extensive experience with managing Contract Research Organization (CRO) for the syntheses of key building blocks * Extensive laboratory research and analytical (HPLC, LC - MS, NMR, Flash Column Chromatography) skills
