Description
Summary Senior R&D manager with over 25 years of experience directing research groups within academic, small entrepreneurial biotechnology, and large pharmaceutical company environments for development of both diagnostic and therapeutic products in autoimmunity, inflammation, transplantation, cancer, and infectious disease. Preclinical drug development experience includes both early stage biologics and small molecule candidates. Technical expertise focused in the area of molecular and cellular biology, biochemistry, human genetics, cellular and molecular immunology and immunotherapy. Experience managing intellectual property, evaluating patents and licensing opportunities, and coordinating external R&D collaborations, CROs, and technology transfers. Enjoys establishing new technology and prefers atmosphere encouraging flexibility, synergism, and teamwork. Prior Research Focus Areas Include: * Animal models for autoimmunity, inflammation and cancer, including RA, Lupus, allergy/asthma and hematopoietic and solid xenograft tumors. * Small molecule lead development for signal transduction targets in cancer and immune cell activation and function * T and B Cell surface molecule interactions, T and B cell activation and antigen receptor recognition * Antigen-specific CTL enrichment, activation, expansion using dimeric MHC/Ig complexes * Antigen processing and peptide presentation function of HLA antigens * Diagnostic antigens in autoimmune Type I diabetes * Expression cloning of human cell surface antigens * Phage Library display and screening * Molecular events following DNA-mediated Gene Transfer
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