Pharmaxis, Australia Work Values

Daily Duties at Pharmaxis, Australia:

➢ Fragment-based Design: Preliminary Screening and Validation of Fragment Library (using 15N NMR Spectroscopy and Molecular Docking) Targeting Bacterial Disulfide Oxidoreductase (DsbA) to Develop Anti-microbial Agents

What they like about Pharmaxis, Australia:

Working for a company with an emphasis on social values and helping society is a clear and important priority for you - a critical factor in who you choose to work for. In contrast to other factors, you place an organization's reputation for fairness and concern for the community above most other aspects of the company. As you search for a new job opportunity, it is usually possible to find out if the company is involved in the community and/or if it is addressing problems and issues in society. Pay special attention to non-profit organizations and those specifically involved in social action. Moreover, speaking with current and former employees should enlighten you to perceptions of the fairness of the company's leaders and the treatment of employees.

Tags

Medicinal chemistry, Drug Design , Organic Synthesis or synthetic chemist, Fragment-based Design, Molecular modeling, Structure-based drug discovery

Skills

Drug Discovery 9 Years Experience in Drug Discovery and Development ➢ Experience in hit to lead identification, SAR development and lead optimization to increase the affinity, selectivity (to reduce the potential side effects), efficacy/potency and me, Teaching Experience The University of Sydney, Australia ➢ Teaching assistant: Supervised and guided students in organic chemistry, computational drug design and biochemistry laboratory techniques. Emphasized keeping complete and accurate scientific not, Organic Synthesis ➢ Practical experience in carrying out various synthetic organic reactions, method development, asymmetric synthesis and multi-parallel (step) synthesis of small or large molecules in gram and milligram scales. , Pharmacology ➢ Practical experience in Two-electrode voltage clamp method, Patch clamp method, Confocal microscopy, Radio-ligand binding assay, RT-PCR and Western blotting, β-Secretase and HIV protease in-vitro assays. , Molecular Modeling ➢ Hit to lead discovery (Virtual screening and Molecular docking), ➢ Lead optimization (Molecular docking, Pharmacophore modeling and scaffold hopping, 3D QSAR, Structure-, ligand- and fragment-based lead optimization) and ➢ A, Analytical Techniques ➢ Experience in maintenance and handling of HPLC, Fluorescence Spectrophotometer, Polarimeter, Microwave and Automated Multiple Organic Synthesizer and Automated Flash Chromatography Instruments. , Structural Elucidation ➢ Well versed with structural elucidation using FT-IR, NMR (1H, 13C, 19F and 31P), 2D NMR (COSY, NOESY, HMBC and HMQC), and Mass Spectroscopy (LCMS/GCMS/MALDI-TOF-TOF).

These are some of the questions we asked our climbers about their experiences with Pharmaxis, Australia: