Purdue University Work Values

Daily Duties at Purdue University:

Projects: ➢ Design and Synthesis of Novel CXCR-4 Antagonists with Potent Anti-HIV Activity ➢ Structure-guided Design and Synthesis of High-affinity P’2 Ligands as Potent HIV-1 Protease Inhibitors ➢ Structure-based Design of Potent and Highly Selective β-Secretase Inhibitors for the Treatment of Alzheimer’s Disease ➢ Discovery of New Class of Endonuclease Inhibitors of Influenza Virus using Pharmacophore Modeling, Structure-based Docking and Scaffold Hopping Approach ➢ Structure-based Design and Synthesis of Potent and Selective CDC7 Inhibitors as Anti-cancer Agents In charge of Prof. Ghosh group Instrumental Lab at Purdue University, USA. Train and guide (under) graduate students and manage their respective research projects Determine in-vitro potency of β-secretase and HIV-PR inhibitors for Ghosh research labs. Designed and reviewed Prof. Ghosh’s various national and international medicinal chemistry grants. Reviewed various research articles from JMC, BMCL, ACS Med. Chem. Lett. and ChemMedChem

What they like about Purdue University:

A hiring company that offers alternative approaches to pay, performance bonuses, and/or equity in the firm is very attractive to you. You're generally less interested in working for an organization offering only traditional, salary-based compensation, one with limited opportunity to acquire equity in the firm, or one that does not actively promote skill development. In addition, you are more likely to choose a company that offers a variety of internal career options, with defined career paths. You view the learning of new skills and development of your expertise as key to your career advancement. These aspects of an organization may become even more important to you as you progress in your field, and are especially critical if you change career or occupation.

Tags

Medicinal chemistry, Drug Design , Organic Synthesis or synthetic chemist, Fragment-based Design, Molecular modeling, Structure-based drug discovery

Skills

Drug Discovery 9 Years Experience in Drug Discovery and Development ➢ Experience in hit to lead identification, SAR development and lead optimization to increase the affinity, selectivity (to reduce the potential side effects), efficacy/potency and me, Teaching Experience The University of Sydney, Australia ➢ Teaching assistant: Supervised and guided students in organic chemistry, computational drug design and biochemistry laboratory techniques. Emphasized keeping complete and accurate scientific not, Organic Synthesis ➢ Practical experience in carrying out various synthetic organic reactions, method development, asymmetric synthesis and multi-parallel (step) synthesis of small or large molecules in gram and milligram scales. , Pharmacology ➢ Practical experience in Two-electrode voltage clamp method, Patch clamp method, Confocal microscopy, Radio-ligand binding assay, RT-PCR and Western blotting, β-Secretase and HIV protease in-vitro assays. , Molecular Modeling ➢ Hit to lead discovery (Virtual screening and Molecular docking), ➢ Lead optimization (Molecular docking, Pharmacophore modeling and scaffold hopping, 3D QSAR, Structure-, ligand- and fragment-based lead optimization) and ➢ A, Analytical Techniques ➢ Experience in maintenance and handling of HPLC, Fluorescence Spectrophotometer, Polarimeter, Microwave and Automated Multiple Organic Synthesizer and Automated Flash Chromatography Instruments. , Structural Elucidation ➢ Well versed with structural elucidation using FT-IR, NMR (1H, 13C, 19F and 31P), 2D NMR (COSY, NOESY, HMBC and HMQC), and Mass Spectroscopy (LCMS/GCMS/MALDI-TOF-TOF).

These are some of the questions we asked our climbers about their experiences with Purdue University: