Human Hookworm Vaccine Initiative, Sabin Vaccine Institute, Gwu Work Values

Daily Duties at Human Hookworm Vaccine Initiative, Sabin Vaccine Institute, Gwu:

Led a group of scientists and technicians to express and purify hookworm and schistosoma antigens for pre-clinical studies. Develop robust scalable processes and transfer of technology for cGMP manufacturing of human hookworm vaccine candidates. Managed a bioprocess development facility.

What they like about Human Hookworm Vaccine Initiative, Sabin Vaccine Institute, Gwu:

Working in an organization that is technologically advanced, creative, and innovative is critical in your assessment of hiring companies. Less important to you are stability of the organization, the length of time an organization has been in business, and the business' plans for the future. You prefer a fast-moving company that will take risks to achieve its goals and objectives. The length of time the company has been in business is irrelevant. Maintaining status quo is unnecessary. You thrive on change, uncertainty and the upside of potential business risks, especially those associated with innovation. Stability for the long haul is not nearly as important as is working in an atmosphere that is charged with a sense of urgency and constant change.

Tags

Protein Purification, Process Development, Technology Transfer, Vaccine Development, Viral Vaccines, Fermentation, Protein Expression, cGMP Manufacturing

Skills

Extensive experience in the development and optimization of scalable and robust fermentation processes (using Bioflo 3000 and fermentors with Biocommand software, micro, ultra and crossflow filtration systems) under GLP and cGMP guidelines. , Highly Experienced in the development and optimization of scalable and robust purification processes of recombinant antigens using various chromatographic Techniques and AKTA purification systems (AKTA purifier, AKTA Explorer; etc.) with UNICORN software,, Highly Experienced in Technology transfer of fermentation and purification processes to pilot scale cGMP manufacturing facilities. Experienced working in a cGMP environment and cGMP documentation practices., Experienced in writing Standard Operating Procedures (SOPs) and Batch Production Records (BPRs). Preparation of Technical reports and contributing to CMC sections of INDs. , Extensive experience in analytical characterization of recombinant antigens using various Techniques including- HPLC, IEF, SDS-PAGE, Western blots, etc. , Experienced in developing and implementing improvements to clinical manufacturing processes., Reviewed SBIR and STIR grant proposals for NSF, USA., Experienced in supervising, motivating and mentoring junior staff-scientists and engineers., Knowledge of using statistical approach-Design of Experiments (DoE) for process development (to screen chromatographic media/ conditions for optimum binding, wash, elution, and cleaning-in-place and determine adsorption isotherms). Knowledge of the concep, Published the results of scientific research studies in peer reviewed journals and presented at national and international scientific meetings., Evaluated Ph. D and Master level research theses. , Taught Bioinorganic, Advanced Inorganic, Bioanalytical, Analytical and Organo-metallic Chemistry courses to graduate and undergraduate students., Presented scientific results at national and international conferences.

These are some of the questions we asked our climbers about their experiences with Human Hookworm Vaccine Initiative, Sabin Vaccine Institute, Gwu: