Bristol Myers Squibb Work Values

Daily Duties at Bristol Myers Squibb:

• Technical liaison for a project that was outsourced to an overseas vendor for IND supplies. Traveled to vendor site to oversee the manufacture of the API. • Developed a new process for making an anti-obesity drug, including a novel coupling reaction to form a biaryl ether. This new process replaced the discovery process that entailed the use of a potentially dangerous intermediate. A patent has been filed for the new process. As a project leader represented Process R & D at the DMCT (Drug Manufacturing Co-ordination Team) and PWG (Project Working Group). • Represented Process R & D at a meeting with the FDA to discuss issues associated with a candidate in the metabolic diseases area. • Developed a process to make a key intermediate for a candidate in the metabolics area in the pilot plant. Part of the project team that won the departmental award for outstanding process research and development. • Developed a difficult palladium-catalyzed cyanation process that was successfully scaled up in the pilot plant. • Developed a process to make a key intermediate (penultimate) for a candidate in the AIDS therapeutic area. Successfully scaled up the process in the pilot plant. • Member, BMS Unrestricted Award Committee for young faculty members ($100,000/year; recent award winners include Profs. David MacMillan, Gregory Fu, Matt Shair and Jim Morken). • Developed a new process for making an oral cPLA2 inhibitor for the treatment of steroid-responsive dermatosis. • Developed a new process for making an anticancer agent. Developed a new isolation protocol for a chiral β-lactam. • Developed a new method for the synthesis of chiral α-hydroxy amides using a triazole-mediated coupling between n-Sulfinylanilines and chiral α-hydroxy acids. This new methodology has been published in Tetrahedron Letters. Used this new methodology to make BMS-270394, an RARγ agonist. The new methodology replaced the original discovery synthesis, which was not scalable.

What they like about Bristol Myers Squibb:

You give high priority to hiring firms with prestige. Market reputation and prestige of a firm may be determined through on-line research, and conversations with individuals working in your target industry. Note that firms "in the public eye" receive a great deal more critical publicity and attention than those operating with more anonymity. So as you assess your employment opportunities, be sure to seek out the positive aspects of the firm's reputation in addition to noting negative publicity the company may have received.

Tags

process development, process research, scaleup, research, scientist, manufacture, process research and development, GMP, project leader, Managed CMOs, IND and NDA Filings, Bay Area, Associate Director, Senior Scientist, Los Angeles, San Diego, Senior Research Investigator, Senior Research Chemist

Skills

Sales Support, Software Implementation, Requirements Analysis & Specification, Problem Solving, GMP Regulations, Manage internal and external CMOs/CSOs, Project Leader, IND and NDA Filings, Chemistry Literature, Supervising People, Process Research and Development

These are some of the questions we asked our climbers about their experiences with Bristol Myers Squibb: